You, Me and Dupree [Portuguese]

Kate Hudson

Molly

Owen Wilson

Dupree

Matt Dillon

Carl

Michael Douglas

Mr. Thompson

Seth Rogen

Neil

Amanda Detmer

Annie

Ralph Ting

Toshi

Todd Stashwick

Tony

Bill Hader

Mark

Lance Armstrong

Self

Jason Winer

Eddie

Sidney S. Liufau

Paco

Billy Gardell

Bartender Dave

Eli Vargas

Aaron

Houston Mack

Dougie

Bob Larkin

Army Veteran

Suzanne Ford

Thompson's Secretary

Claudia Choi

Carl's Secretary